Abstract #1353
Measuring Deuterium Relaxation Times in Human Brain at 7T following D2O Loading
Daniel Cocking1,2, Robin Damion2,3,4, Hester Franks5, Daniel Wilkinson6,7, Matthew Brook4,6,8, Dorothee Auer2,3,4, and Richard Bowtell1,2,4
1School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, 2Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 3Mental Health and Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United Kingdom, 4NIHR Nottingham Biomedical Research Centre/Nottingham Clinical Research Facilities, Queen's Medical Centre, Nottingham, United Kingdom, 5Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham, United Kingdom, 6MRC-Versus Arthritis Centre for Musculosketal Ageing Research, University of Nottingham, Nottingham, United Kingdom, 7Division of Medical Sciences and Graduate Entry Medicine, School of Medicine, University of Nottingham, Nottingham, United Kingdom, 8School of Life Sciences, University of Nottingham, Nottingham, United Kingdom
Synopsis
Deuterium magnetic resonance measurements are of growing interest in the field of metabolic imaging. Four subjects were loaded with D2O to ~1.5% enrichment over a 6-week period for a parallel study of immune cell proteomics. We report T1 and T2* relaxation times of deuterium in HDO measured from cerebral spinal fluid (CSF), white matter (WM) and grey matter (GM) in vivo, using a 7T Philips Achieva scanner with a dual-tuned 2H/1H birdcage coil. 2H T1 values are significantly shorter than corresponding values for 1H in H2O, due to the quadrupolar 2H relaxation, whilst T2* values are comparable to 1H values.
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