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Abstract #1354

2H multi-echo bSSFP highlights pancreatic ductal adenocarcinomas and distinguishes them from pancreatitis in murine models

Elton Tadeu Montrazi1, Qingjia Bao2, Dana Peters3, Keren Sasson1, Lilach Agemy1, Avigdor Scherz1, and Lucio Frydman1
1Weizmann Institute of Science, Rehovot, Israel, 2Chinese Academy of Sciences, Wuhan, China, 3Yale School of Medicine, New Haven, CT, United States


Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest of cancers. We recently showed that deuterium metabolic imaging (DMI) can serve as a potential method for PDAC’s detection; we also demonstrated that multi-echo balanced steady-state free precession (ME-bSSFP) can greatly increase DMI’s SNR per unit time compared to CSI acquisitions. This study synergizes these aspects, to provide high resolution maps on the metabolic kinetic of PDAC and pancreatitis mouse models. ME-bSSFP at 15.2T showed that lactate accumulated in different kinds of tumors. In general, glucose was also uptaken by the tumors, and HDO concentrated in them.

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