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Abstract #1355

Deuterated α-ketoglutarate has the potential to detect the isocitrate dehydrogenase 1 mutation in low-grade gliomas.

Celine Taglang1, Georgios Batsios1, Meryssa Tran1, Anne-Marie Gillespie1, Sabrina Ronen1, and Pavithra Viswanath1
1Radiology, University of California San Francisco, San Francisco, CA, United States


2H-MRS is a novel method of imaging flux through metabolic pathways. Here, we show that 2H-MRS can be used to probe the isocitrate dehydrogenase 1 mutation (IDHmut), which catalyzes production of the oncometabolite 2-hydroxyglutarate (2-HG) in low-grade gliomas. Our results indicate that 2-HG production from [3,3’-2H]-α-KG can be specifically observed in IDHmut cells. Importantly, treatment with an IDHmut inhibitor, which is in clinical trials for low-grade glioma patients, results in a significant reduction in 2-HG production from [3,3’-2H]-α-KG in IDHmut cells. Our results point to the potential of [3,3’-2H]-α-KG as a probe of glioma IDHmut status and response to therapy.

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