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Abstract #1356

Prior knowledge fitting of 2H-labeled glutamate in the 1H MRS spectrum to map neural metabolism following ingestion of deuterated glucose

Neil Wilson1, Abigail Cember1, Laurie Rich1, Puneet Bagga2, Ravi PR Nanga1, Sophia Swago3, Deepa Thakuri1, Mark Elliott1, Mitchell Schnall1, John Detre4, and Ravinder Reddy1
1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Diagnostic Imaging, St Jude Children's Research Hospital, Memphis, TN, United States, 3Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 4Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States


Deuterium metabolic imaging (DMI) has brought about a renewed interest in the application of 2H-labeled substrates to map metabolism in vivo, yet deuterium spectroscopy remains challenging. We have shown that metabolism of deuterium-labeled glucose can be observed in the proton spectrum through a reduction in signal of downstream metabolites in a technique called quantitative exchange label turnover MRS (qMRS). Here, we show that prior knowledge fitting that includes unlabeled as well as deuterium-labeled forms of glutamate can be used to map neural metabolism reliably with qMRS.

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