Abstract #1357

Deuterium metabolic imaging of a healthy human brain after oral glucose uptake on a clinical 3T MRI scanner

Michael Vaeggemose^1,2, Rolf F. Schulte³, Christoffer Laustsen², Esben Søvsø Szocska Hansen², and Nikolaj Bøgh²

¹GE Healtcare, Broendby, Denmark, ²MR Research Centre, Department of Clinical Medicine, Aarhus University, Aarhus N, Denmark, ³GE Healtcare, Munich, Germany

Synopsis

Deuterium metabolic imaging (DMI) has emerged as a novel biomarker comparable to ¹⁸FDG PET by adding quantitative metabolic kinetic capabilities at high field (>3T). The main barrier for widespread clinical adoption, is the availability of high field clinical scanners. The aim of this study is to determine if DMI for neurological applications is feasible on a clinical 3T MRI scanner. Our findings suggests that it is indeed feasible, and that metabolic breakdown product (Glutamine/Glutamate) can be quantified around 120 min after ingestion.

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