Abstract #1358

Monitoring water uptake in the human body during oral loading of heavy water using deuterium magnetic resonance

Daniel Cocking^1,2, Robin Damion^2,3,4, Hester Franks⁵, Daniel Wilkinson^6,7, Dorothee Auer^2,3,4, Matthew Brook^4,6,8, and Richard Bowtell^1,2,4

¹School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, ²Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ³Mental Health and Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United Kingdom, ⁴NIHR Nottingham Biomedical Research Centre/Nottingham Clinical Research Facilities, Queen's Medical Centre, Nottingham, United Kingdom, ⁵Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham, United Kingdom, ⁶MRC-Versus Arthritis Centre for Musculosketal Ageing Research, University of Nottingham, Nottingham, United Kingdom, ⁷Division of Medical Sciences and Graduate Entry Medicine, School of Medicine, University of Nottingham, Nottingham, United Kingdom, ⁸School of Life Sciences, University of Nottingham, Nottingham, United Kingdom

Synopsis

Deuterium magnetic resonance imaging and spectroscopy at 7T has been used to follow the deuterium concentration in the brain over an ~eight-hour period while subjects orally-loaded with D₂O to 100x natural abundance. Changes in deuterium concentration of ~ 0.1% can be readily monitored in ²H spectra acquired in 1 minute and images acquired in 7.5 minutes. The change in deuterium concentration estimated from ²H spectra is in agreement with the value calculated from cumulative D₂O dose and body mass and the signal changes measured from ROIs in the brain have similar time-courses, with relative signal strengths dictated by T₂*-weighting.

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