Abstract #1358
Monitoring water uptake in the human body during oral loading of heavy water using deuterium magnetic resonance
Daniel Cocking1,2, Robin Damion2,3,4, Hester Franks5, Daniel Wilkinson6,7, Dorothee Auer2,3,4, Matthew Brook4,6,8, and Richard Bowtell1,2,4
1School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, 2Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 3Mental Health and Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, United Kingdom, 4NIHR Nottingham Biomedical Research Centre/Nottingham Clinical Research Facilities, Queen's Medical Centre, Nottingham, United Kingdom, 5Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham, United Kingdom, 6MRC-Versus Arthritis Centre for Musculosketal Ageing Research, University of Nottingham, Nottingham, United Kingdom, 7Division of Medical Sciences and Graduate Entry Medicine, School of Medicine, University of Nottingham, Nottingham, United Kingdom, 8School of Life Sciences, University of Nottingham, Nottingham, United Kingdom
Synopsis
Deuterium magnetic resonance imaging and spectroscopy at 7T has been used to follow the deuterium concentration in the brain over an ~eight-hour period while subjects orally-loaded with D2O to 100x natural abundance. Changes in deuterium concentration of ~ 0.1% can be readily monitored in 2H spectra acquired in 1 minute and images acquired in 7.5 minutes. The change in deuterium concentration estimated from 2H spectra is in agreement with the value calculated from cumulative D2O dose and body mass and the signal changes measured from ROIs in the brain have similar time-courses, with relative signal strengths dictated by T2*-weighting.
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