Abstract #1360

An old tracer learns new tricks: Imaging cerebral glucose uptake with deuterated 2-deoxy-d-glucose-2,2-d2

Xiao Gao^1,2,3, Jeremy Gordon², Kai Qiao², Ilona Polvoy², Tanner Nickles^2,3, David Wilson², and Myriam M. Chaumeil^1,2,3

¹1 Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco, San Francisco, CA, United States, ²Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ³UC Berkeley-UCSF Bioengineering Program, University of California, San Francisco, San Francisco, CA, United States

Synopsis

2-deoxy-d-glucose (2-DG) is a glucose analog widely used in FDG-PET imaging as a biological tracer of glucose uptake. This study innovatively redirects its application in ²H NMR by using a deuterated version of 2-DG (2-DG-d2) and explores its imaging potential in mapping glucose uptake without ionizing radiation. A workflow is described here regarding multi-band RF pulse design and bSSFP sequence optimization, which enables a rapid ²H imaging with high sensitivity. Both in vitro and in vivo imaging results have validated the pulse sequence’s specificity and sensitivity of detecting 2-DG-d2 with high spatial resolution, inspiring its further implementation in the future.

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