2-deoxy-d-glucose (2-DG) is a glucose analog widely used in FDG-PET imaging as a biological tracer of glucose uptake. This study innovatively redirects its application in 2H NMR by using a deuterated version of 2-DG (2-DG-d2) and explores its imaging potential in mapping glucose uptake without ionizing radiation. A workflow is described here regarding multi-band RF pulse design and bSSFP sequence optimization, which enables a rapid 2H imaging with high sensitivity. Both in vitro and in vivo imaging results have validated the pulse sequence’s specificity and sensitivity of detecting 2-DG-d2 with high spatial resolution, inspiring its further implementation in the future.
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