1H-[13C] NMR spectroscopy is a powerful tool to study metabolic information in human brain. At 7T, the proton-observed carbon-edited (POCE) method provides high sensitivity and improved spectral resolution. However, the application in human brain has more constraints due to high RF power deposition at 7T. In this study, we investigated the performance of the STEAM-based POCE sequence without decoupling to reduce the RF power. The phantom experiments and the Monte Carlo simulations demonstrated high-quality 1H-[13C] MR spectra and the accurate quantification of 13C-labeled glutamate and glutamine without decoupling at 7T.
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