Abstract #1362

Optimization of a Phase-Cycled bSSFP for Improved SNR-efficiency in Fluorine-19 MRI at 3T

Lawrence Michael Lechuga¹, Paul Begovatz², Bruce D Collick³, and Sean B Fain⁴

¹Medical physics, University of Wisconsin Madison, Madison, WI, United States, ²Medical Physics, University of Wisconsin, Madison, Madison, WI, United States, ³Radiology, University of Wisconsin, Madison, Madison, WI, United States, ⁴Radiology, University of Iowa, Iowa City, WI, United States

Synopsis

The focus of this work is on the optimization of fluorine-19 enabled SPGR, bSSFP, and phase cycled bSSFP (bSSFP-C) pulse sequence parameters to improve signal acquisition efficiency for perfluoropolyether (PFPE) at 3T with a multi-channel coil. Bloch simulations and subsequent experimental validation were performed to determine the parameters to maximize the SNR-efficiency for each sequence. Acquisitions of the optimized SPGR, bSSFP, and bSSFP-C were then assessed for their achieved SNR-efficiency. bSSFP and bSSFP-C demonstrated increased sensitivity compared to SPGR. Feasibility of bSSFP-C with parallel imaging demonstrated the ability to reduce scan times by 2-fold without compromising the qualitative image quality.

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