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Abstract #1362

Optimization of a Phase-Cycled bSSFP for Improved SNR-efficiency in Fluorine-19 MRI at 3T

Lawrence Michael Lechuga1, Paul Begovatz2, Bruce D Collick3, and Sean B Fain4
1Medical physics, University of Wisconsin Madison, Madison, WI, United States, 2Medical Physics, University of Wisconsin, Madison, Madison, WI, United States, 3Radiology, University of Wisconsin, Madison, Madison, WI, United States, 4Radiology, University of Iowa, Iowa City, WI, United States


The focus of this work is on the optimization of fluorine-19 enabled SPGR, bSSFP, and phase cycled bSSFP (bSSFP-C) pulse sequence parameters to improve signal acquisition efficiency for perfluoropolyether (PFPE) at 3T with a multi-channel coil. Bloch simulations and subsequent experimental validation were performed to determine the parameters to maximize the SNR-efficiency for each sequence. Acquisitions of the optimized SPGR, bSSFP, and bSSFP-C were then assessed for their achieved SNR-efficiency. bSSFP and bSSFP-C demonstrated increased sensitivity compared to SPGR. Feasibility of bSSFP-C with parallel imaging demonstrated the ability to reduce scan times by 2-fold without compromising the qualitative image quality.

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