The focus of this work is on the optimization of fluorine-19 enabled SPGR, bSSFP, and phase cycled bSSFP (bSSFP-C) pulse sequence parameters to improve signal acquisition efficiency for perfluoropolyether (PFPE) at 3T with a multi-channel coil. Bloch simulations and subsequent experimental validation were performed to determine the parameters to maximize the SNR-efficiency for each sequence. Acquisitions of the optimized SPGR, bSSFP, and bSSFP-C were then assessed for their achieved SNR-efficiency. bSSFP and bSSFP-C demonstrated increased sensitivity compared to SPGR. Feasibility of bSSFP-C with parallel imaging demonstrated the ability to reduce scan times by 2-fold without compromising the qualitative image quality.