Abstract #1363

1H-31P Cross-polarization: A new frontier to study myelin in white matter

Alex Ensworth^1,2, Cariad-Arianna Knight¹, Piotr Kozlowski^1,2,3,4, Cornelia Laule^1,2,3,5, Alex L. MacKay^1,3,4, and Carl A. Michal¹

¹Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ²International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada, ³Radiology, University of British Columbia, Vancouver, BC, Canada, ⁴UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, ⁵Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada

Synopsis

Phosphorus (³¹P) nuclear magnetic resonance spectroscopy (NMR) has the potential to play a valuable role in the characterization of myelin due to the concentration of ³¹P present in myelin phospholipids. This study demonstrates the feasibility of detecting ³¹P through cross polarization (CP) and magnetization transfer (MT) from hydrogen in preserved murine spinal cord and fresh porcine brain. The results demonstrate the detection of myelin phospholipids through these NMR techniques and provide compelling proof of concept for the potential applicability of MT-CP in ³¹P MRI for non-ambiguous myelin characterization in vivo.

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