The determination of tissue pH under varying cellular conditions by means of 31P MRS is challenging. We propose a concept for a dictionary-based approach for pH estimation under different chemical conditions. As proof-of-concept, we demonstrate its feasibility for a limited subset of conditions using the chemical shifts of ATP and their dependence on pH and magnesium. For the presented subset, the estimated pH values are in good agreement with the prepared values. However, for application to in vivo data, an extension of the dictionary to include other influences, e.g. of other ions, is required and the subject of ongoing work.
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