In this study, we performed brain surface-based morphometry to evaluate changes in sulcal depth after sound therapy in patients with idiopathic tinnitus. Our results showed that sulcal depth was significantly reduced in the left medial temporal cortex (MTC) and right somatosensory and motor cortex (SMC) of patients with tinnitus compared to the healthy controls, but increased significantly at 24 weeks after sound therapy. Therefore, sulcal depth in the auditory sensory regions of the brain is a potential neuroimaging biomarker for evaluating treatment efficacy in tinnitus patients.
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