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Abstract #1393

White matter perivascular space enlargement in cerebral small vessel disease indicates cerebral amyloid angiopathy pattern changes

hui hong1 and minming zhang2
1the second affiliated hospital of zhejiang university, school of medicine, hangzhou, China, 2radiology, the second affiliated hospital of zhejiang university, school of medicine, hangzhou, China

Synopsis

The enlargement of white matter perivascular space(PVS) is highly CAA related, however lack of studies investigated its role in stable pattern CSVD patients, we hypothesis that CSVD patients with white matter PVS enlargement indicates a CAA pattern changes.

Here we compared patients with and without white matter PVS enlargement from imaging manifestation, imaging mechanism and clinical cognitive ability. We foud that patients with PVS enlargenmet showed a pattern similar to previous symptomatic CAA, that is more lobar microbleed, more interstitial fluid retention and significantly lower global cognitive ability. Extra dignosis and treament should be carried out to this pattern CSVD.

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