HP-Xe Xenon Transfer Contrast (XTC) imaging produces exchange maps between gas (GP) and red blood cell (RBC) and tissue plasma (TP). However, it is difficult to separate the effects of exchange between RBC or TP due to unintended depolarization by the saturation pulse. We introduce a correction method to isolate exchange due to either compartment. The correction method measures depolarization due to saturation at a distance Δ, —the separation between the DP resonances—away from the compartment’s resonance frequency. The corrected maps generated here show that greater correction is needed for discrete pulses and higher power pulses.