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Abstract #1401

Influence of group-oriented registration on functional ventilation parameters derived by 3D phase-resolved functional lung ventilation MRI

Filip Klimeš1,2, Andreas Voskrebenzev1,2, Marcel Gutberlet1,2, Cristian Crisosto1,2, Robert Grimm3, Frank Wacker1,2, and Jens Vogel-Claussen1,2
1Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, 2Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Centre for Lung Research (DZL), Hannover, Germany, 3MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany


Demonstration of a high repeatability is a mandatory step prior to the usage of new methods in clinical routine. Good to moderate repeatability of 3D phase-resolved functional lung (PREFUL) MRI was shown before. In this study, group-oriented registration (GOREG) was compared to stepwise registration regarding the repeatability of 3D PREFUL ventilation parameters in 30 study participants. Furthermore, image sharpness and structural similarity (SSIM) were assessed. An increased repeatability of dynamic 3D PREFUL ventilation parameters was observed using the GOREG approach. Also, image sharpness and SSIM values were significantly higher for measurements assessed with GOREG registration.

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