Abstract #1401

Influence of group-oriented registration on functional ventilation parameters derived by 3D phase-resolved functional lung ventilation MRI

Filip Klimeš^1,2, Andreas Voskrebenzev^1,2, Marcel Gutberlet^1,2, Cristian Crisosto^1,2, Robert Grimm³, Frank Wacker^1,2, and Jens Vogel-Claussen^1,2

¹Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, ²Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Centre for Lung Research (DZL), Hannover, Germany, ³MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany

Synopsis

Demonstration of a high repeatability is a mandatory step prior to the usage of new methods in clinical routine. Good to moderate repeatability of 3D phase-resolved functional lung (PREFUL) MRI was shown before. In this study, group-oriented registration (GOREG) was compared to stepwise registration regarding the repeatability of 3D PREFUL ventilation parameters in 30 study participants. Furthermore, image sharpness and structural similarity (SSIM) were assessed. An increased repeatability of dynamic 3D PREFUL ventilation parameters was observed using the GOREG approach. Also, image sharpness and SSIM values were significantly higher for measurements assessed with GOREG registration.

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