Synovial inflammation (synovitis) is present in the majority of people with Osteoarthritis(OA) and has been linked with pain, disease severity and progression of knee OA. However, synovitis is not widely studied due to challenges differentiating synovial inflammation from adjacent fluid on conventional MRI and contraindications and time, cost and complexity of gadolinium-based contrast-enhanced methods. In this work, we evaluate the feasibility of the intravoxel incoherent motion(IVIM) imaging model for characterization of synovitis activity. By characterizing the diffusion from synovial fluid effusions, we showed that the intravoxel signal from effusions can be removed allowing isolation of diffusion effects from the synovium.
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