Abstract #1408

Simultaneous morphologic and quantitative imaging of the knee joint using pseudo-3D MIXTURE sequences: from deliberation to implementation

Teresa Nolte¹, Shuo Zhang², Nicola Pridöhl¹, Malin Ciba¹, Masami Yoneyama³, Christiane Kuhl¹, and Sven Nebelung⁴

¹Diagnostic and Interventional Radiology, University Hospital Aachen, Aachen, Germany, ²Philips GmbH Market DACH, Hamburg, Germany, ³Philips Japan, Tokyo, Japan, ⁴Clinic for Diagnostic and Interventional Radiology, Uniklinik RWTH Aachen University, Aachen, Germany

Synopsis

This work aimed to propose a clinical sequence platform for simultaneous morphologic and quantitative imaging of joints and identified TSE-based MIXTURE (Multi-Interleaved X-prepared Turbo-Spin Echo with Intuitive Relaxometry) sequences in terms of PDFS-T₂ and T₁-T_1ρFS combinations for clinical implementation. Even though capable of isotropic resolution, MIXTURE sequences were acquired as pseudo-3D (thicker slices, higher in-plane resolution) to match standard-clinical 2D TSE sequences. After identification of clinical demands, MIXTURE sequences were systematically optimized, while maintaining clinically feasible acquisition times of 5:00 min (PDFS-T₂ for T₂-mapping) and 6:40 min (T₁-T_1ρFS for T_1ρ-mapping), and evaluated in a cadaveric human knee cartilage defect model.

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