Recent studies on the brain suggest a link between brain function and biomechanics of brain. In this study we develop a novel simulation framework to investigate blood flow-induced deformation caused by increased neural activity in brain tissue considering its mechanical properties. We further investigate its impact in simulated fMRI experiments. Our results demonstrate that the displacement in gyrus induced by local volume and stiffness change might not be directly resolved due to limited fMRI resolution, but can lead to artifacts when interpreting measurements at layer-level resolution. Our findings may help to systematically analyze potential resulting artefacts in high resolution fMRI.
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