Quantitative T1D assessment in lipid membranes: Jeener-Broekaert NMR vs. ihMT MRI
Andreea Hertanu1,2, Lucas Soustelle1,2, Ludovic de Rochefort1,2, Axelle Grélard3, Antoine Loquet3, Erick J. Dufourc3, Gopal Varma4, David C. Alsop4, Guillaume Duhamel1,2, and Olivier M. Girard1,2
1Aix Marseille Univ, CNRS, CRMBM, Marseille, France, 2APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, 3CBMN UMR 5248, CNRS, University of Bordeaux, Bordeaux INP, Pessac, France, 4Division of MR Research, Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States
The dipolar order relaxation time (T1D) is a probe of membrane dynamics and microstructure and could serve to further understand the relationship between the myelin membrane integrity and its biological function. In this work, the ability of quantitative inhomogeneous Magnetization Transfer (qihMT) to estimate the several T1D components of a synthetic lipid membrane system, a surrogate for the myelin membrane, was evaluated by comparison with the gold standard method for T1D quantification, the NMR Jeener-Broekaert (JB) sequence.
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