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Abstract #1427

A novel clinical prostate diffusion MRI approach for combined measurement of ADC and non-monoexponential diffusion

Stefan Kuczera1, Fredrik Langkilde1, and Stephan E. Maier1,2
1Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Gothenborg, Sweden, 2Department of Radiology, Brigham Women’s Hospital, Harvard Medical School, Boston, MA, United States


A novel clinical protocol for prostate diffusion imaging is presented. The commonly applied strategy of averaging MR signal at a small number of b-values is replaced by the acquisition of a whole range of b-values in conjunction with a model fitting post precessing step. With no increase in acquisition time, our results show that the same image quality can be achieved. As a main benefit, modelling is made more consistent and largely b-value independent for both the simple ADC model, as well as for more complex signal representations such as the kurtosis model.

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