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Abstract #1426

Time dependence at ultra-high diffusion weighting reveals fast compartmental exchange in rat cortex in vivo

Jonas Lynge Olesen1,2, Andrada Ianus3, Noam Shemesh3, and Sune Nørhøj Jespersen1,2
1Center of Functionally Integrative Neuroscience (CFIN) and MINDLab, Aarhus University, Aarhus, Denmark, 2Department of Physics and Astronomy, Aarhus University, Aarhus, Denmark, 3Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal


The potential effect of compartmental water exchange and somas on the diffusion MRI signal in grey matter tissue are currently open questions with considerable implications for biophysical modelling of grey matter at (pre-)clinical diffusion time scales. Recent studies have begun to tackle these questions and found evidence that compartmental water exchange dominates the diffusion time dependence. Here, we extend the application of the Standard Model with exchange between the neurites and extracellular water (SMEX) to in vivo rat brain and again find evidence for exchange-dominated time dependence with very short neurite residence time on the order of 2 ms.

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