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Abstract #1425

Novel particle-based spatial stochastic Bloch simulation applied to LDH-mediated pyruvate conversion

Dylan Archer Dingwell1,2 and Charles H Cunningham1,2
1Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada


In order to model signal mechanisms relevant to HP 13C MRI of lactate, we developed a novel particle-based MR model which extends the Brownian dynamics simulator Smoldyn. The model performs concurrent calculation of a forward solution of the Bloch equations for simulated particles using quaternion rotations. Reaction kinetics of LDH-mediated conversion of pyruvate to lactate were simulated and compared to a benchtop experiment (LDH activity assay). Modelling of particle compartmentalization and motion were also tested in simulated structures.

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