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Abstract #1440

Development of a fluorescent, MRI contrast agent (Gd-DOTA-coumarin) to improve measurement of Gd concentration

Ayesha Bharadwaj Das1, Jin Zhang1, Ching-Hsuan Tung1, James Kelly1, Youssef Zaim Wadghiri2, and Gene Kim1
1Radiology, Weill Cornell Medicine, New York, NY, United States, 2Radiology, Grossman School of Medicine, New York, NY, United States


Measurement of gadolinium concentration in DCE-MRI is a significant step but remains challenging. In this study, we developed a novel Gd-based contrast agent Gd-DOTA-coumarin that can directly quantify gadolinium concentration through florescence measurement using a plate reader. The preliminary results shows that the longitudinal relaxivity in plasma at 7T is 8.6 mM-1s-1 and the limit of detection for the fluorescence measurement is 100 µM in blood. This new agent has also been successfully used for in vivo MRI experiments.

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