Measurement of gadolinium concentration in DCE-MRI is a significant step but remains challenging. In this study, we developed a novel Gd-based contrast agent Gd-DOTA-coumarin that can directly quantify gadolinium concentration through florescence measurement using a plate reader. The preliminary results shows that the longitudinal relaxivity in plasma at 7T is 8.6 mM-1s-1 and the limit of detection for the fluorescence measurement is 100 µM in blood. This new agent has also been successfully used for in vivo MRI experiments.
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