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Abstract #1441

A serial dilution study of four Gadolinium-based contrast agents for the detection of low-Gd concentration

Emilie Poirion1, Corentine Marie2, Dann Fournier1, Remy Carrion1, and Julien Savatovsky1
1Hospital Foundation A. de Rothschild, Imaging department, Paris, France, PARIS, France, 2Paris Brain Institute, Paris, France


Gadolinium-enhanced imaging provides valuable information in clinical practice. Concerns raised by gadolinium depositions favors strategies reducing injected doses in patients requiring repeated scans. We designed four phantoms containing serial dilutions of four gadolinium-based contrast agents to compare their efficacy for low-Gd concentration detection in clinically used MR sequences, based on signal intensity and contrast-to-noise ratio. We performed a preliminary study comparing T1-TSE, FLAIR and FLAIR with optimized parameters on these phantoms. The optimized FLAIR sequence shows an efficient detection of low concentrations, in particular using gadobutrol or gadoteridol.

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