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Abstract #1442

Influence of Glycosaminoglycans on the Transmetallation and Transchelation Kinetics of Gadolinium from GBCAs in the Presence of ZnCl2

Patrick Werner1, Patrick Schuenke2, Matthias Taupitz3, and Leif Schröder1
1Deutsches Krebsforschungszentrum, Heidelberg, Germany, 2Physikalisch-Technische Bundesanstalt, Berlin, Germany, 3Charite, Berlin, Germany


Relaxation rates in aqueous solutions containing 30-100 µM heparin as well as 150 µM GBCA were measured as a function of time. Different ZnCl2 stimuli with concentrations between 0.125-4 mM were used as competing ions that initiate a transmetallation and a transchelation process of the Gd3+ ion from GBCAs to glycosaminoglycans. The time resolved relaxometry measurements indicate that glycosaminoglycans play a concentration-dependent double role as competing chelator structures. They foster the thermodynamic instability of intact GBCA by sequestering Gd3+ from the contrast agent but simultaneously interact with competing ions and thus cause a reduced kinetic instability.

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