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Abstract #1451

Evaluating acquisition and preprocessing methods for diffusion MRI in the cervical spinal cord

Kurt Schilling1, Anna J.E. Combes2, Logan Prock2, Kristin P. O'Grady1, Bennett A Landman2, and Seth A Smith1
1Vanderbilt University Medical Center, Nashville, TN, United States, 2Vanderbilt University, Nashville, TN, United States


The aim of this study was to evaluate acquisition and preprocessing strategies for diffusion MRI in the cervical spinal cord. We tested 6 acquisition and 5 preprocessing strategies, and quantified evaluation criteria, and found that pipelines that include distortion correction significantly improve data quality. However, motion and lack of cardiac triggering significantly impact quality measures. Standard diffusion processing packages need to be adapted and modified for spinal cord microstructure to ensure accurate and robust diffusion quantification.

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