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Abstract #1452

Thalamic Involvement in the Pediatric Chronic Spinal Cord Injured Population with Respect to the Severity of Injury

KiChang Kang1, Kristen Fleming1, Anish V. Sathe1, Jennifer Muller1, Devon Middleton1, Feroze Mohamed1, Laura Krisa1, and Mahdi Alizadeh1
1Thomas Jefferson University, Philadelphia, PA, United States


Little is known about microstructural alterations in the thalamus following spinal cord injury (SCI), especially in the pediatric population. In this study, we used diffusion tensor imaging (DTI) derived metrics to characterize microstructural changes in thalamic nuclei of pediatric subjects with chronic SCIs with respect to the severity of injury based on the American Spinal Injury Association Impairment Scale (AIS). We report significant differences in mean diffusion metrics in thalamic nuclei that are suggestive of microstructural alterations between different AIS classifications.

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