Myelin-sensitive MRI metrics correlate with inflammation in human traumatic spinal cord injury
Sarah Rosemary Morris1,2,3, Taylor Swift-LaPointe2, Andrew Yung1,3,4, Valentin Prevost1,3,4, Shana George1, Andrew Bauman4, Piotr Kozlowski1,2,3,4, Farah Samadi1,5, Caron Fournier1,5, Lisa Parker6, Kevin Dong1, Femke Streijger1, Veronica Hirsch-Reinshagen1,5,6, G.R. Wayne Wayne Moore1,5,6, Brian K Kwon1,7, and Cornelia Laule1,2,3,5
1International Collaboration on Repair Discoveries (ICORD), Vancouver, BC, Canada, 2Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, 3Radiology, University of British Columbia, Vancouver, BC, Canada, 4Faculty of Medicine, UBC MRI Research Centre, Vancouver, BC, Canada, 5Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, 6Vancouver General Hospital, Vancouver, BC, Canada, 7Orthopaedics, University of British Columbia, Vancouver, BC, Canada
We investigated the correlation of inhomogeneous magnetisation transfer ratio (ihMTR), myelin water fraction (MWF) and intra/extra-cellular water geometric mean T2 (I/EW gmT2) with the distribution of inflammatory cells as measured by HLA-DR and CD68 histological staining for macrophages and activated microglia in human traumatic spinal cord injury. We found that ihMTR and MWF decreases were strongly correlated with the presence of HLA/CD68+ immune cells in white matter and both ihMTR and MWF were strongly correlated with LFB, a stain for myelin lipids. Our results demonstrate a strong link between ihMTR and MWF and inflammation.
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