Abstract #1453

Myelin-sensitive MRI metrics correlate with inflammation in human traumatic spinal cord injury

Sarah Rosemary Morris^1,2,3, Taylor Swift-LaPointe², Andrew Yung^1,3,4, Valentin Prevost^1,3,4, Shana George¹, Andrew Bauman⁴, Piotr Kozlowski^1,2,3,4, Farah Samadi^1,5, Caron Fournier^1,5, Lisa Parker⁶, Kevin Dong¹, Femke Streijger¹, Veronica Hirsch-Reinshagen^1,5,6, G.R. Wayne Wayne Moore^1,5,6, Brian K Kwon^1,7, and Cornelia Laule^1,2,3,5

¹International Collaboration on Repair Discoveries (ICORD), Vancouver, BC, Canada, ²Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, ³Radiology, University of British Columbia, Vancouver, BC, Canada, ⁴Faculty of Medicine, UBC MRI Research Centre, Vancouver, BC, Canada, ⁵Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, ⁶Vancouver General Hospital, Vancouver, BC, Canada, ⁷Orthopaedics, University of British Columbia, Vancouver, BC, Canada

Synopsis

We investigated the correlation of inhomogeneous magnetisation transfer ratio (ihMTR), myelin water fraction (MWF) and intra/extra-cellular water geometric mean T₂ (I/EW gmT₂) with the distribution of inflammatory cells as measured by HLA-DR and CD68 histological staining for macrophages and activated microglia in human traumatic spinal cord injury. We found that ihMTR and MWF decreases were strongly correlated with the presence of HLA/CD68+ immune cells in white matter and both ihMTR and MWF were strongly correlated with LFB, a stain for myelin lipids. Our results demonstrate a strong link between ihMTR and MWF and inflammation.

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