Abstract #1454

Making myelin water imaging “normal”: Robust acquisition for cervical cord with low peripheral nerve stimulation

Sharada Balaji¹, Adam Dvorak¹, Neale Wiley¹, Laura Barlow², Irene M. Vavasour^3,4, Alex MacKay^1,3, and Shannon H. Kolind^1,3,4,5

¹Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ²MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, ³Radiology, University of British Columbia, Vancouver, BC, Canada, ⁴International Collaboration on Repair Discoveries, Vancouver, BC, Canada, ⁵Medicine, University of British Columbia, Vancouver, BC, Canada

Synopsis

The standard myelin water imaging (MWI) sequence for cervical spinal cord, 3D gradient and spin echo (GRASE), was modified to allow scanning in “normal mode” (limiting imaging parameters that may cause physiologic stress) for patients who may not tolerate peripheral nerve stimulation or tissue heating due to MR-conditional implants or medical issues. Traditional 32-echo GRASE was replaced with 48-echo GRASE in normal mode. Myelin water fraction maps from the new sequence had better repeatability than the standard sequence. 48-echo GRASE is the recommended sequence for MWI in spinal cord, particularly for subjects who cannot be scanned outside of normal mode.

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