Abstract #1455

Lumbosacral spinal cord changes after acute spinal cord injury: preliminary results of an MRI study

Silvan Büeler¹, Patrick Freund², Thomas M. Kessler¹, Martina D. Liechti¹, and Gergely David^1,2

¹Department of Neuro-Urology, Balgrist University Hospital, University of Zürich, Zürich, Switzerland, ²Spinal Cord Injury Center, Balgrist University Hospital, University of Zürich, Zürich, Switzerland

Synopsis

Imaging of the lumbosacral enlargement (LSE) has previously demonstrated remote degeneration below a cervical spinal cord injury leading to progressive atrophy of grey and white matter. Here, we investigate, for the first time, neurodegeneration in the conus medullaris (including the LSE) after acute spinal cord injury using an optimized multi-echo gradient-echo sequence. At 1-month after injury, preliminary results show lower grey matter volume in the conus medullaris. This is the first MRI investigation indicating remote tissue-specific volumetric changes in the conus medullaris in spinal cord injury.

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