Abstract #1459

Characterization of the spinal cord fMRI signal in the healthy subjects and in multiple sclerosis patients

Michela Fratini¹, Laura Maugeri², Mauro Di Nuzzo³, Marta Moraschi⁴, Fabio Mangini⁵, Daniele Mascali³, Valerio Pisani⁵, Ugo Nocentini⁵, and Federico Giove³

¹CNR- Nanotec, Roma, Italy, ²CNR- Nanotec, Lecce, Italy, ³CREF-Centro Fermi, Roma, Italy, ⁴campus biomedico, Roma, Italy, ⁵fondazione Santa Lucia, Roma, Italy

Synopsis

Functional Magnetic Resonance Imaging (fMRI) has become one of the most powerful tools in neuroscience research, with promising applications in clinical practice. Particularly, fMRI based on blood oxygenation level dependent (BOLD) contrast has gained a primary role in the study of human brain and spinal cord, for the characterization of normal and pathological brain/spinal cord (SC) activity. In this framework, we have studied and report the characterization of the functional response of the SC to a multilevel motor task, designed to assess the linearity of the hemodynamic response as a function of the intensity of a graded task.

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