Abstract #1460
Cord compression from stenosis reduces resting-state functional connectivity in the cervical spinal cord
Anna JE Combes1,2, Kristin P O'Grady1,2, Baxter P Rogers1,2, Wuraola Adesinasi3, Logan Prock1, Delaney Houston1, Hamid Shah3, David Edwards4, Silky Chotai3, Byron F Stephens5, Li Min Chen1,2, Seth A Smith1,2,6, and John C Gore1,2,6
1Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, 2Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 3Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, United States, 4Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, United States, 5Orthopaedic Surgery, Vanderbilt University Medical Center, Nashville, TN, United States, 6Biomedical Engineering, Vanderbilt University, Nashville, TN, United States
Synopsis
Spinal cord stenosis presents with highly variable clinical manifestations and prognoses. Resting-state functional MRI of the cord could provide complementary information in addition to structural measures. We sought to determine whether functional connectivity (FC) measures were altered in patients with compression of the lower cervical spinal cord, and whether those were related to morphometric measures at and above the level of pathology. Compression in the lower segments was significantly associated with lower FC of the ventral and dorsal networks in patients. This finding is a first step in exploring the FC features of the cord in compressive pathology.
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