Abstract #1460

Cord compression from stenosis reduces resting-state functional connectivity in the cervical spinal cord

Anna JE Combes^1,2, Kristin P O'Grady^1,2, Baxter P Rogers^1,2, Wuraola Adesinasi³, Logan Prock¹, Delaney Houston¹, Hamid Shah³, David Edwards⁴, Silky Chotai³, Byron F Stephens⁵, Li Min Chen^1,2, Seth A Smith^1,2,6, and John C Gore^1,2,6

¹Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, ²Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ³Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, United States, ⁴Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, United States, ⁵Orthopaedic Surgery, Vanderbilt University Medical Center, Nashville, TN, United States, ⁶Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

Synopsis

Spinal cord stenosis presents with highly variable clinical manifestations and prognoses. Resting-state functional MRI of the cord could provide complementary information in addition to structural measures. We sought to determine whether functional connectivity (FC) measures were altered in patients with compression of the lower cervical spinal cord, and whether those were related to morphometric measures at and above the level of pathology. Compression in the lower segments was significantly associated with lower FC of the ventral and dorsal networks in patients. This finding is a first step in exploring the FC features of the cord in compressive pathology.

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