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Abstract #1466

Assessing Drug Effect on the Velocity Pulsatility in the Perforating Arteries of the Basal Ganglia at 3T-MRI in Pseudoxanthoma Elasticum

Stanley D.T. Pham1, Rick J. van Tuijl1, Jonas W. Bartstra1, Tim C. van den Beukel1, Geert Jan Biessels2, Pim A. de Jong1, Wilko Spiering3, Birgitta K. Velthuis1, and Jaco J.M. Zwanenburg1
1Radiology, UMC Utrecht, Utrecht, Netherlands, 2Neurology and Neurosurgery, UMC Utrecht, Utrecht, Netherlands, 3Vascular Medicine, UMC Utrecht, Utrecht, Netherlands


This feasibility study aimed to detect drug effects on perforating artery velocity as measured with two-dimensional phase-contrast (2D-PC) velocity measurements at 3T-MRI. Seventeen patients with pseudoxanthoma elasticum were included into a treatment group who received etidronate (n=9) and into a placebo group (n=8). No significant differences were found between both groups at baseline and one-year follow-up. In the etidronate group, mean velocity (Vmean) was significantly higher at follow-up (5.61 [4.77–6.45] cm/s) compared to baseline (4.80 [4.05–5.54] cm/s). In the placebo group, Vmean did not increase significantly. Measuring drug effects was feasible using 2D-PC measurements at 3T-MRI.

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