Abstract #1466

Assessing Drug Effect on the Velocity Pulsatility in the Perforating Arteries of the Basal Ganglia at 3T-MRI in Pseudoxanthoma Elasticum

Stanley D.T. Pham¹, Rick J. van Tuijl¹, Jonas W. Bartstra¹, Tim C. van den Beukel¹, Geert Jan Biessels², Pim A. de Jong¹, Wilko Spiering³, Birgitta K. Velthuis¹, and Jaco J.M. Zwanenburg¹

¹Radiology, UMC Utrecht, Utrecht, Netherlands, ²Neurology and Neurosurgery, UMC Utrecht, Utrecht, Netherlands, ³Vascular Medicine, UMC Utrecht, Utrecht, Netherlands

Synopsis

This feasibility study aimed to detect drug effects on perforating artery velocity as measured with two-dimensional phase-contrast (2D-PC) velocity measurements at 3T-MRI. Seventeen patients with pseudoxanthoma elasticum were included into a treatment group who received etidronate (n=9) and into a placebo group (n=8). No significant differences were found between both groups at baseline and one-year follow-up. In the etidronate group, mean velocity (V_mean) was significantly higher at follow-up (5.61 [4.77–6.45] cm/s) compared to baseline (4.80 [4.05–5.54] cm/s). In the placebo group, V_mean did not increase significantly. Measuring drug effects was feasible using 2D-PC measurements at 3T-MRI.

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