Abstract #1467

Comparison of cerebral oxygen extraction fraction using ASE and TRUST methods in patients with sickle cell disease and healthy controls

Slim Fellah¹, Chunwei Ying¹, Kristin Guilliams¹, Melanie Fields¹, Yasheng Chen¹, Joben Lewis¹, Amy Mirro¹, Rachel Cohen¹, Nkemdilim Igwe¹, Cihat Eldeniz¹, Dengrong Jiang², Hanzhang Lu², Jin-Moo Lee¹, Andria Ford¹, and Hongyu An¹

¹Washington University School of Medicine, Saint Louis, MO, United States, ²Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

We evaluated cerebral oxygen extraction fraction (OEF) in patients with sickle cell disease (SCD) and controls using two MR techniques: asymmetric spin echo (ASE) and T2-relaxation-under-spin-tagging (TRUST). We hypothesized that both methods would yield similar OEF and that TRUST-derived OEF would be elevated in patients with SCD vs. controls as previously found using ASE-derived OEF. ASE-derived and TRUST-derived OEF using the Lu 2012 calibration model showed a positive correlation (rho=0.823, p<0.001). Conversely, ASE-derived vs. TRUST-derived OEF using the Bush 2021 model showed a negative association (rho=-0.569, p<0.001). The directionality of these associations was heavily dependent on the calibration model used.

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