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Abstract #1467

Comparison of cerebral oxygen extraction fraction using ASE and TRUST methods in patients with sickle cell disease and healthy controls

Slim Fellah1, Chunwei Ying1, Kristin Guilliams1, Melanie Fields1, Yasheng Chen1, Joben Lewis1, Amy Mirro1, Rachel Cohen1, Nkemdilim Igwe1, Cihat Eldeniz1, Dengrong Jiang2, Hanzhang Lu2, Jin-Moo Lee1, Andria Ford1, and Hongyu An1
1Washington University School of Medicine, Saint Louis, MO, United States, 2Johns Hopkins University School of Medicine, Baltimore, MD, United States


We evaluated cerebral oxygen extraction fraction (OEF) in patients with sickle cell disease (SCD) and controls using two MR techniques: asymmetric spin echo (ASE) and T2-relaxation-under-spin-tagging (TRUST). We hypothesized that both methods would yield similar OEF and that TRUST-derived OEF would be elevated in patients with SCD vs. controls as previously found using ASE-derived OEF. ASE-derived and TRUST-derived OEF using the Lu 2012 calibration model showed a positive correlation (rho=0.823, p<0.001). Conversely, ASE-derived vs. TRUST-derived OEF using the Bush 2021 model showed a negative association (rho=-0.569, p<0.001). The directionality of these associations was heavily dependent on the calibration model used.

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