Relative cerebral blood volume reduction in hyperintense brain regions of glioma patients treated with proton radio(chemo)therapy
Katharina Witzmann1,2, Felix Raschke1,2, Tim Wesemann3, Steffen Appold2,4, Mechthild Krause1,2,4,5,6, Jennifer Linn3, and Esther G.C. Troost1,2,4,5,6
1Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiooncology – OncoRay, Dresden, Germany, 2OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany, 3Institute of Neuroradiology, University Hospital Carl Gustav Carus and Medical Faculty of Technische Universität, Dresden, Germany, 4Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, 5German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany, 6National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, and; Helmholtz Association / Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany
Imaging biomarkers capable of distinguishing between tumor recurrence and treatment effect are of high relevance for radiation therapy. In 14 glioma patients, we analyzed changes in relative cerebral blood volume (rCBV) in areas of hyperintensities on T2-weighted magnetic resonance imaging (MRI) appearing after irradiation with protons. rCBV values were evaluated comparing the baseline and the latest follow-up measurement both visually and based on histograms. A significant rCBV perfusion decrease was observed in those hyperintensities, which may be interpreted as treatment effect. Further work is needed correlating the rCBV changes with histology and patient outcome.
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