Moyamoya disease is a cerebrovascular disease where changes to oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) are important parameters to assess the risk of future ischemic stroke. By applying a microvasculature model to dynamic susceptibility contrast (DSC) perfusion data parametric maps of both OEF and CMRO2 can be generated. For both OEF and CMRO2 significant differences between affected and unaffected vascular territorial regions were found. OEF and CMRO2 derived from DSC perfusion shows promise in detecting cerebral hemodynamic impairment in patients with moyamoya disease. However, further investigations are needed to clarify the clinical potential.
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