Meeting Banner
Abstract #1472

Oxygen Extraction Fraction and Cerebral Metabolic Rate of Oxygen derived from DSC-MRI in Patients with Moyamoya Disease

Markus Fahlström1, Anders Lewén2, Per Enblad2, and Johan Wikström1
1Surgical Sciences, Uppsala University, Uppsala, Sweden, 2Neuroscience, Uppsala University, Uppsala, Sweden


Moyamoya disease is a cerebrovascular disease where changes to oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) are important parameters to assess the risk of future ischemic stroke. By applying a microvasculature model to dynamic susceptibility contrast (DSC) perfusion data parametric maps of both OEF and CMRO2 can be generated. For both OEF and CMRO2 significant differences between affected and unaffected vascular territorial regions were found. OEF and CMRO2 derived from DSC perfusion shows promise in detecting cerebral hemodynamic impairment in patients with moyamoya disease. However, further investigations are needed to clarify the clinical potential.

This abstract and the presentation materials are available to members only; a login is required.

Join Here