Abstract #1476

CEST Imaging vs. DWI vs. FDG-PET/CT: Therapeutic Effect Prediction for Chemoradiotherapy in Non-Small Cell Lung Cancer Patients

Yoshiharu Ohno^1,2, Masao Yui³, Daisuke Takenaka⁴, Takeshi Yoshikawa⁴, Kaori Yamamoto³, Masato Ikedo³, Saki Takeda⁵, Akiyoshi Iwase⁵, Satomu Hanamatsu¹, Yuki Obama¹, Hiroyuki Nagata¹, Takahiro Ueda¹, Hirotaka Ikeda¹, Kazuhiro Murayama², and Hiroshi Toyama¹

¹Radiology, Fujita Health University School of Medicine, Toyoake, Japan, ²Joint Research Laboratory of Advanced Medical Imaging, Fujita Health University School of Medicine, Toyoake, Japan, ³Canon Medical Systems Corporation, Otawara, Japan, ⁴Diagnostic Radiology, Hyogo Cancer Center, Akashi, Japan, ⁵Radiology, Fujita Health University Hospital, Toyoake, Japan

Synopsis

We hypothesize that CEST imaging has a potential for therapeutic effect prediction in NSCLC patients treated with chemoradiotherapy and may be at least as valuable as DWI and FDG-PET/CT. Moreover, combined predictors may improve therapeutic effect prediction capability, when compared with single predictor from MRI or PET/CT. The purpose of this study was to compare the capability of therapeutic effect prediction for chemoradiotherapy among CEST imaging, DWI, FDG-PET/CT and combined predictors from MRI and PET/CT in NSCLC patients.

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