mcDESPOT was used to measure single-component T2 relaxation time (T2Single) and the bi-component T2 parameter fraction of the fast relaxing macromolecular bound water component (FF) of the cartilage of the knee at 3.0T in 10 subjects with ACL reconstruction and 10 control subjects. There were significant differences (p<0.05) between ACL reconstruction and control subjects on 5 of 6 articular surfaces of the knee for FF compared with 2 of 6 surfaces for T2Single with FF having higher absolute effect size than T2Single for all surfaces. The results demonstrate the superiority of bi-component over single-component T2 analysis for detecting cartilage degeneration.
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