ACL T2* metrics were evaluated over the course of the menstrual cycle. During the pre-ovulatory phase, normally ovulating case subjects exhibited significantly shortened mean and median T2*S metrics compared to the post-ovulatory phase. Anovulatory control subjects displayed no significant changes in any ACL T2* metrics over time. Findings suggest that an increase in collagen bound water (T2*S) is present within the ACL during the pre-ovulatory phase, when both ACL-injury risk and anterior knee laxity are also increased.
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