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Abstract #1485

Dynamic Changes in Lung Water Density and Volume with Changes in Body Position

David Thomas Goodhart1, Justin Grenier1, Rob Stobbe1, Peter Seres1, and Richard Thompson1
1The Department of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada


We aim to describe the dynamic response of the distribution of lung water to the change in position from standing to supine. An efficient UTE MRI trajectory (Yarnball) provided 3D images (free-breathing, 74 seconds acquisition) in 3 volunteers, with 10 repeated scans over ~14 minutes. Lung water density (LWD) increased over time but total lung water content remained constant, consistent with a measured decrease in lung volume over time. LWD increased by a larger extent towards the back, suggesting a larger lung volume reduction in gravity dependent regions (the back) over time. Steady-state LWD was not achieved in 14 minutes.

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