Imaging biomarkers of ventilation in Interstitial Lung Disease from 129Xe and Oxygen Enhanced 1H MRI
Marta Tibiletti1, James A Eaden2, Jo Naish1,3, Paul JC Hughes2, John C Waterton1,4, Matthew J Heaton1, Nazia Chaudhuri5, Sarah Skeoch6, Ian N Bruce7,8, Stephen A Bianchi9, Jim M Wild2,10, and Geoff JM Parker1,11
1Bioxydyn Ltd, Manchester, United Kingdom, 2POLARIS, University of Sheffield MRI unit, The University of Sheffield, Sheffield, United Kingdom, 3MCMR, Manchester University NHS Foundation Trust, Manchester, United Kingdom, 4Centre for Imaging Sciences, University of Manchester, Manchester, United Kingdom, 5North West Lung Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom, 6Royal National Hospital for Rheumatic Diseases, Royal United Hospitals Bath NHS Foundation Trust, Bath, United Kingdom, 7NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom, 8Centre for Musculoskeletal Research, University of Manchester, Manchester, United Kingdom, 9Academic Directorate of Respiratory Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom, 10nsigneo Institute for in silico Medicine, Sheffield, United Kingdom, 11Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom
Interstitial lung diseases (ILD) are a heterogeneous group of conditions exhibiting inflammation and scarring of the lung parenchyma. Here, we compare imaging biomarkers from hyperpolarised 129Xe ventilation MRI and oxygen-enhanced MRI (OE-MRI) with standard pulmonary function tests in cohorts of ILD patients with mixed origins. We also evaluated whether disease resolution or progression could be detected over two visits. None of the imaging biomarkers considered completely differentiated ILD subtypes. OE-MRI biomarkers are feasible in ILD patients and do not correlate strongly with PFT. Both OE-MRI and 129Xe MRI revealed spatially heterogeneous ventilation in patients with DI-ILD and IPF.
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