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Abstract #1483

PREFUL-MRI evaluation of dynamic hyperinflation induced by metronome-paced tachypnea in COPD patients

Robin A. Müller1,2, Filip Klimeš1,2, Andreas Voskrebenzev1,2, Lea Behrendt1,2, Till F. Kaireit1,2, Cristian Crisosto1,2, Maximilian Zubke1,2, Martin R. Prince3,4, Christopher C. Cooper5, R. Graham Barr6, Jens M. Hohlfeld7,8, and Jens Vogel-Claussen1,2
1Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, 2Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany, 3Department of Radiology, Weill Cornell Medical College, New York, NY, United States, 4Department of Radiology, Columbia College of Physicians and Surgeons, New York, NY, United States, 5Exercise Physiology Research Laboratory, Departments of Medicine and Physiology, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States, 6Division of General Medicine, Department of Medicine, New York-Presbyterian/Columbia University Irving Medical Center, New York, NY, United States, 7Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany, 8Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany


Metronome-paced tachypnea (MPT) is a technique where a patient breathes with a fixed frequency (40 breaths / minute). MPT induces dynamic hyperinflation and allows investigation of potential stress-driven effects on ventilation parameters. Fourteen patients with chronic obstructive pulmonary disease (COPD) underwent phase-resolved functional lung (PREFUL) MRI with 2D coronal lung MR images acquired during normal tidal breathing (NTB) and MPT. Compared to NTB, ventilation defect percentages increased in COPD patients during MPT. Thus, MPT in conjunction with PREFUL-MRI will be further investigated as a possible sensible ventilation test for COPD patients.

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