Abstract #1482

Examining lung microstructure using ¹⁹F MR diffusion imaging in COPD patients

Arnd Jonathan Obert^1,2, Marcel Gutberlet^1,2, Agilo Luitger Kern^1,2, Till Frederik Kaireit^1,2, Julian Glandorf^1,2, Tawfik Moher Alsady^1,2, Frank Wacker^1,2, Jens M. Hohlfeld^2,3,4, and Jens Vogel-Claussen^1,2

¹Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, ²Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany, ³Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany, ⁴Department of Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany

Synopsis

Diffusion of fluorinated gas in the short-time regime was measured using multiple gradient echo sequences with a single pair of trapezoidal gradient pulses. Pulmonary alveolar surface-to-volume ratio (S/V) was calculated using a first-order approximation of the time-dependent diffusion in a study with 20 healthy volunteers and 22 patients with chronic obstructive pulmonary disease (COPD). Median surface-to-volume ratio is significantly decreased in COPD patients compared to healthy volunteers (P<.0001). No significant difference was found between measurements within 7 days. Linear correlations were found with S/V from hyperpolarized ¹²⁹Xe MRI (r=0.85, P=.001) and the forced expiratory volume in one second (r=0.68, P<.0001).

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Examining lung microstructure using 19F MR diffusion imaging in COPD patients

Synopsis

Examining lung microstructure using ¹⁹F MR diffusion imaging in COPD patients