Examining lung microstructure using 19F MR diffusion imaging in COPD patients
Arnd Jonathan Obert1,2, Marcel Gutberlet1,2, Agilo Luitger Kern1,2, Till Frederik Kaireit1,2, Julian Glandorf1,2, Tawfik Moher Alsady1,2, Frank Wacker1,2, Jens M. Hohlfeld2,3,4, and Jens Vogel-Claussen1,2
1Institute for Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, 2Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany, 3Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany, 4Department of Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany
Diffusion of fluorinated gas in the short-time regime was measured using multiple gradient echo sequences with a single pair of trapezoidal gradient pulses. Pulmonary alveolar surface-to-volume ratio (S/V) was calculated using a first-order approximation of the time-dependent diffusion in a study with 20 healthy volunteers and 22 patients with chronic obstructive pulmonary disease (COPD). Median surface-to-volume ratio is significantly decreased in COPD patients compared to healthy volunteers (P<.0001). No significant difference was found between measurements within 7 days. Linear correlations were found with S/V from hyperpolarized 129Xe MRI (r=0.85, P=.001) and the forced expiratory volume in one second (r=0.68, P<.0001).
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