Oxygen-enhanced MRI of the lung at 3 tesla: R2* contrast in smokers and non-smokers
Mina Kim1, Josephine H. Naish2,3, Marta Tibiletti2, Sarah H. Needleman1, Adam Szmul1, David M. Higgins4, James P. B. O’Connor5,6, and Geoff J. M. Parker1,2
1Centre for Medical Image Computing (CMIC), University College London, London, United Kingdom, 2Bioxydyn Limited, Manchester, United Kingdom, 3BHF Manchester Centre for Heart and Lung Magnetic Resonance Research (MCMR), Manchester University NHS Foundation Trust, Manchester, United Kingdom, 4Philips, Farnborough, United Kingdom, 5Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom, 6Division of Radiotherapy and Imaging, Institute of Cancer Research, London, United Kingdom
T1-weighted dynamic lung OE-MRI is challenging at 3 T using gradient echo acquisitions due to decreased T1 relaxivity of oxygen and substantial ∆R2* contribution. We implemented a dual echo T1-FFE-based method at 3 T and evaluated signal enhancement behaviour and ∆R2*. The proposed method is shown to produce negative contrast on oxygen enhancement signal due to dominance of ∆R2* at TE larger than 0.4 ms. We also demonstrated that the contrast property of the percentage signal enhancement (PSE) is TE dependent. Longer TE enables differentiation on PSE values between non-smokers and smokers.
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