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Abstract #1480

Use of Phase Resolved Functional Lung Imaging (PREFUL) to Assess Response to Kaftrio®┬áTherapy in Cystic Fibrosis

Zachary Peggs1, Jonathan Brooke2, Shahidehalsadat Safavi3,4, Andrew Prayle5,6, Christabella Ng5,6, Jan Alappadan1, Christopher Bradley1, Andrew Cooper1, Samal Munidasa7,8, Brandon Zanette8, Giles Santyr7,8, Helen Barr9, Alan R Smyth5,6, Ian Hall2, Susan Francis1, and Penny Gowland1
1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2The Nottingham Biomedical Research Centre (BRC), Respiratory Medicine Dept, School of Medicine, University of Nottingham, Nottingham, United Kingdom, 3The Toronto Lung Transplant Program, University Hospital Network, Toronto, ON, Canada, 4Respirology Medicine Dept, University of Toronto, Toronto, ON, Canada, 5School of Medicine, University of Nottingham, Nottingham, United Kingdom, 6Nottingham NIHR Biomedical Research Centre, Nottingham, United Kingdom, 7The Hospital for Sick Children, Toronto, ON, Canada; Dept. of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 8The Hospital for Sick Children, Toronto, ON, Canada, University of Toronto, Toronto, ON, Canada, 9The Wolfson Centre for Adult Cystic Fibrosis, Nottingham City Hospital, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom

Synopsis

Phase resolved functional lung imaging (PREFUL) was carried out before and 12 weeks after commencement of Kaftrio® therapy in a small Cystic Fibrosis (CF) group, and in healthy controls (HC). No significant differences were found in measures characterising the PREFUL signal between HC and CF, or before and after Kaftrio® therapy. This could be explained by the small sample size or lack of age matching. It was found that fractional ventilation measures with PREFUL can be sensitive to subjective thresholding and the method of image registration. Also, the impact of irregular breathing patterns, especially in patients, should be further explored.

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