Knee osteoarthritis results from inflammatory, mechanical, and metabolic processes, leading to chronic degenerative changes. The purpose of this study was to investigate the cross-sectional associations between thigh muscle volume or intermuscular fat volume, and relative muscle sizes, from T1-weighted MR images of 100 thighs, and radiographic knee osteoarthritis (ROA) using Kellgren-Lawrence grades. The results showed that lower volumes of the quadriceps and the anterior muscle compartment of the thigh relative to total muscle volume, as well as relative higher hamstring muscle volume were associated with presence of ROA (P<0.05).
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