Abstract #1495

Compressed sensing and the use of 3D UTE acquisition for high-resolution accelerated 23NA imaging at 3T

Cameron Villarreal¹, Xin Shen¹, Ali Calgar Ozen², Serhat Ilbey², Mark Chiew³, Ahmad Alhulial⁴, Evan Pogue⁵, Uzay Emir^1,5, and Deva Chan¹

¹Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States, ²Department of Radiology, Medical Physics, Medical Center, University of Freiburg, Freiburg, Germany, ³Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom, ⁴College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia, ⁵School of Health Sciences, Purdue University, West Lafayette, IN, United States

Synopsis

There is a need for methods to detect early compositional changes during musculoskeletal diseases like osteoarthritis, but current diagnostic tools . Sodium (²³Na) MRI enables quantification of sodium content which is correlated with cartilage health. However, several limitations preclude its widespread clinical use including long scan times and low resolution. We have developed a UTE ²³Na MRI sequence with rosette acquisition capable of overcoming some of these limitations. In this study we demonstrate the feasibility of reducing our acquisition time through compressed sensing while conserving signal quality in a healthy human knee.

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