Compressed sensing and the use of 3D UTE acquisition for high-resolution accelerated 23NA imaging at 3T
Cameron Villarreal1, Xin Shen1, Ali Calgar Ozen2, Serhat Ilbey2, Mark Chiew3, Ahmad Alhulial4, Evan Pogue5, Uzay Emir1,5, and Deva Chan1
1Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States, 2Department of Radiology, Medical Physics, Medical Center, University of Freiburg, Freiburg, Germany, 3Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom, 4College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia, 5School of Health Sciences, Purdue University, West Lafayette, IN, United States
There is a need for methods to detect early compositional changes during musculoskeletal diseases like osteoarthritis, but current diagnostic tools . Sodium (23Na) MRI enables quantification of sodium content which is correlated with cartilage health. However, several limitations preclude its widespread clinical use including long scan times and low resolution. We have developed a UTE 23Na MRI sequence with rosette acquisition capable of overcoming some of these limitations. In this study we demonstrate the feasibility of reducing our acquisition time through compressed sensing while conserving signal quality in a healthy human knee.
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