Abstract #1494

Correlation of Fractional Anisotropy and Histological Measures of Muscle Architecture in Vastus Lateralus in Legs with Injured ACL

Peter Andrew Hardy¹, Christopher Fry², Anders Andersen³, Katherine Thompson⁴, Thorsten Feiweier⁵, and Brian Noehren⁶

¹Radiology, University of Kentucky, Lexington, KY, United States, ²Athletic Training and Clinical Nutrition, University of Kentucky, Lexington, KY, United States, ³MRISC, University of Kentucky, Lexington, KY, United States, ⁴Statistics, University of Kentucky, Lexington, KY, United States, ⁵Diagnostic Imaging, Siemens Healthcare, GmbH, Erlangen, Germany, ⁶Physical Therapy, University of Kentucky, Lexington, KY, United States

Synopsis

We measured diffusion tensor properties of the vastus lateralus muscle in 30 subjects who had a torn ACL. DTI was acquired with a stimulated echo acquisition with a diffusion time of 185 ms. From biopsies of the muscle taken simultaneously we developed histological measures of muscle fiber cross sectional area and minimum Feret diameter. Linear regression analysis demonstrated strong association of the fractional anisotropy and minimum Feret diameter.

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