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Abstract #1499

Application of Two Denoising Methods to the Diffusion-Weighted 129Xe MRI and Dynamic Ventilation 19F/129Xe MRI Data Obtained from Normal Rats

Elise Noelle Woodward1, Gregory Lemberskiy2, Matthew S Fox1,3, and Alexei Ouriadov1,3
1Physics and Astronomy, Western University, London, ON, Canada, 2New York University Grossman School of Medicine, New York, NY, United States, 3Lawson Health Research Institute, London, ON, Canada

Synopsis

In this study, we demonstrate the effectiveness of two de-noising methods on diffusion-weighted and dynamic lung imaging in healthy rats using 129Xe and 19F. While the results showed a insignificant difference for denoising method 1 (MP-PCA), de-noising method 2 (MP-PCA preceded by hard-thresholding over a nuclear norm in k-space) showed significant difference in the overall mean Lm and LmD values for ventilation and r (fractional ventilation estimate) for ventilation images.

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