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Abstract #1500

Mapping Free Water in the Brain Using Multiparameter qMRI Combined with an Iterative Fast Exchange Relaxation Model

Ryan McNaughton1,2, Ning Hua2, Lei Zhang3, David Kennedy4, Karl Kuban2, and Hernan Jara2
1Mechanical Engineering, Boston University, Boston, MA, United States, 2Boston University Medical Center, Boston, MA, United States, 3University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 4University of Massachusetts, Worcester, MA, United States


Purpose: To develop an integrated theoretical model and computer algorithms for mapping individually and simultaneously the spatial distributions of free water, alongside myelin and iron. Theory: We solve a fast exchange relaxation model effectively decomposing qMRI maps of nPD, R1, and R2 into maps of free water, myelin, and iron. Results: The image processing technique generates maps of free water, myelin, and iron in the brains of adolescents born extremely preterm. Conclusion: A theoretical framework and image processing pipeline for mapping the distribution of free water has been developed and tested with a cohort of adolescents born extremely preterm.

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